An enlarged liver might not cause symptoms.

When enlarged liver results from liver disease, it might be accompanied by:

• Abdominal pain
• Fatigue
• Nausea and vomiting

Yellowing of the skin and the whites of the eyes (jaundice)

The liver is a large, football-shaped organ found in the upper right portion of your abdomen. The size of the liver varies with age, sex and body size. Many conditions can cause it to enlarge, including:

Liver diseases

• Cirrhosis
• Hepatitis caused by a virus — including hepatitis A, B and C — or caused by infectious mononucleosis
• Nonalcoholic fatty liver disease
• Alcoholic fatty liver disease
• A disorder that causes abnormal protein to accumulate in your liver (amyloidosis)
• A genetic disorder that causes copper to accumulate in your liver (Wilson's disease)
• A disorder that causes iron to accumulate in your liver (hemachromatosis)
• A disorder that causes fatty substances to accumulate in your liver (Gaucher's disease)
• Fluid-filled pockets in the liver (liver cysts)
• Noncancerous liver tumors, including hemangioma and adenoma
• Obstruction of the gallbladder or bile ducts
• Toxic hepatitis

Cancers

• Cancer that begins in another part of the body and spreads to the liver
• Leukemia
• Liver cancer
• Lymphoma

Heart and blood vessel problems

• Blockage of the veins that drain the liver (Budd-Chiari syndrome)
• Heart failure
• Inflammation of the tissue surrounding the heart (pericarditis)

You're more likely to develop an enlarged liver if you have a liver disease. Factors that can increase your risk of liver problems include:

• Excessive alcohol use. Drinking large amounts of alcohol can be damaging to your liver.
• Large doses of medicines, vitamins or supplements.Taking larger than recommended doses of vitamins, supplements, or over-the-counter (OTC) or prescription medicines can increase your risk of liver damage.

Acetaminophen overdose is the most common cause of acute liver failure in the United States. Besides being the ingredient in OTC pain relievers such as Tylenol, it's in more than 600 medications, both OTC and prescription.

Know what's in the medications you take. Read labels. Look for "acetaminophen," "acetam" or "APAP." Check with your doctor if you're not sure what's too much.

• Herbal supplements. Certain supplements, including black cohosh, ma huang and valerian, can increase your risk of liver damage.
• Infections. Infectious diseases, viral, bacterial or parasitic, can increase your risk of liver damage.
• Hepatitis viruses. Hepatitis A, B and C can cause liver damage.
• Poor eating habits. Being overweight increases your risk of liver disease, as does eating unhealthy foods, such as those with excess fat or sugar.